Nail Fungus (Onychomycosis)

Recommended Compound

Itraconazole 1%, Miconazole 2%, Ibuprofen 2% Nail Solution 10ml

-Apply to affected nail(s) twice daily.

Related Data:
Antimicrob Agents Chemother. 1995 Dec;39(12):2610-4

The combination of fluconazole with either ibuprofen, sodium salicylate, or propylparaben resulted in synergistic activity (fractional inhibitory index, < 0.5) against Candida albicans NCYC 620 in a microdilution checkerboard assay. Synergism between miconazole and ibuprofen was also demonstrated. In three or four clinical isolates of C. albicans from AIDS patients, the
combination of fluconazole and ibuprofen was synergistic. Preparation of the inoculum and the growth conditions used were those recommended by the National Committee for Clinical Laboratory Standards for susceptibility testing. A visual estimation of total inhibition of growth and determination of an 80% reduction in the optical density at 492 nm compared with those for the control were taken as endpoints for the calculation of synergy, and a good correlation between both estimates was demonstrated.

Related Compounds

Urea 40% Ointment

-This compound is an excellent choice for severe cases of onychomycosis which require nail avulsion prior to anti-fungal treatment. It should be applied twice daily to the affected nail(s).

Additional Undecylenic Acid

-Certain practitioners have chosen to add this ingredient for its additional anti-fungal properties. We recommend a concentration of 10%.


Med Specialties Compounding Pharmacy

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