Warts (Office & Patient Use)

Office Use

Recommended Compound

Salicylic Acid 30%, Podophyllotoxin 5%, Cantharadin 1% 10ml

Apply as directed. For office use only.

J Am Podiatr Med Assoc. 2008 Nov-Dec;98(6):445-50

METHODS: A retrospective study was conducted of 144 patients with simple or mosaic plantar warts who were treated with a topical, pharmacy-compounded solution of cantharidin, 1%; podophyllotoxin, 5%; and salicylic acid, 30%. Of the 144 patients, 92 were being treated for the first time. None of the 52 previously treated patients had received more than one other type of treatment in the past. RESULTS: After 6 months of follow-up, complete eradication of the plantar warts was noted in 138 of the 144 patients (95.8%). Of these patients, 125 (86.8%) required a single application of the solution, and 13 (9.0%) needed two or more applications. No significant adverse effects or complications were observed. CONCLUSION: A topical solution of cantharidin, podophyllotoxin, and salicylic acid was found to be safe and effective in the treatment of simple and mosaic plantar warts.

Related Compounds

Squraric Acid Dibutylester Immunotherapy (SABDE)

Patients were sensitized with 1% or 2% SADBE in acetone under occlusion, then treated with 0.5% to 5% SADBE applied to their warts every 2 to 4 weeks in the office. RESULTS: Clearing of all warts was seen in 20 of 29 patients (69%), improvement in 3 patients (10%), and no change in 6 patients (21%). Call or e-mail pharmacy for protocol.

Patient Use

Salicylic Acid 25% Lactic Acid 25% Topi-Paint 25gm

Apply to affected area(s) daily and occlude.

Am Fam Physician. 2007 Apr 1;75(7):1001-1002

Review included randomized controlled trials of topical treatments for warts. Five trials (322 total patients) compared six to 12 weeks of treatment with salicylic or lactic acid with placebo. Active treatment had a significantly higher cure rate than placebo (73 versus 48 percent). Only two poor-quality studies compared cryotherapy with placebo. Although no significant difference was found, one study found an unusually low cure rate (9 percent) with cryotherapy, and the other study found an unusually high cure rate (40 percent) with placebo. Two studies comparing salicylic or lactic acid with cryotherapy found no significant difference among the therapies, although they found a trend toward greater benefit with combined therapy than with salicylic or lactic acid alone.

Related Compounds

Zinc Oxide (ZNO) 20% Ointment Deoxy-d-Glucose 0.2%

Int J Dermatol. 2007 Apr;46(4):427-30
CONCLUSION: Topical zinc oxide is an efficacious, painless, and safe therapeutic option for wart treatment.

Salicylic Acid 20% 5-Fluorouracil 5% DDG 0.2% Solution

J Drugs Dermatol. 2006 May;5(5):418-24
Study comparing 5% 5-FU cream under tape occlusion versus tape occlusion alone in 40 patients presenting with plantar warts. Nineteen out of 20 patients (95%) randomized to 5% 5-FU with tape occlusion had complete eradication of all plantar warts within 12 weeks of treatment.

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